The timezone changes work in your favor heading west as well, giving an extra hour here or there of driving.
As boring geographically as the midwestern states can be, they have awesome speed limits. You can cover a good bit of ground with a 75 mph speed limit.
One of the annoying things, however, are the radio stations in western Iowa and Nebraska. The three Cs are mostly all that is available out there (Classics, Country and Christian). So if that's your cup of tea you are golden.
All in all the drive west was pretty fun and quick.